Penton, David and Bandulik, Sascha and Schweda, Frank and Haubs, Sophia and Tauber, Philipp and Reichold, Markus and Cong, Lu Dang and El Wakil, Abeer and Budde, Thomas and Lesage, Florian and Lalli, Enzo and Zennaro, Maria-Christina and Warth, Richard and Barhanin, Jacques (2012) Task3 Potassium Channel Gene Invalidation Causes Low Renin and Salt-Sensitive Arterial Hypertension. ENDOCRINOLOGY, 153 (10). pp. 4740-4748. ISSN 0013-7227, 1945-7170
Full text not available from this repository. (Request a copy)Abstract
Task1 and Task3 potassium channels (Task: tandem of P domains in a weak inward rectifying K+ channel-related acid-sensitive K+ channel) are believed to control the membrane voltage of aldosterone-producing adrenal glomerulosa cells. This study aimed at understanding the role of Task3 for the control of aldosterone secretion. The adrenal phenotype of Task3(-/-) mice was investigated using electrophysiology, adrenal slices, and blood pressure measurements. Primary adrenocortical cells of Task3(-/-) mice were strongly depolarized compared with wild-type (-52 vs. -79 mV), and in fresh adrenal slices Ca2+ signaling of Task3(-/-) glomerulosa cells was abnormal. In living Task3(-/-) mice, the regulation of aldosterone secretion showed specific deficits: Under low Na+ and high K+ diets, protocols known to increase aldosterone, and under standard diet, Task3 inactivation was compensated and aldosterone was normal. However, high Na+ and low K+ diets, two protocols known to lower aldosterone, failed to lower aldosterone in Task3(-/-) mice. The physiological regulation of aldosterone was disturbed: aldosterone-renin ratio, an indicator of autonomous aldosterone secretion, was 3-fold elevated at standard and high Na+ diets. Isolated adrenal glands of Task3(-/-) produced 2-fold more aldosterone. As a consequence, Task3(-/-) mice showed salt-sensitive arterial hypertension (plus 10 mm Hg). In conclusion, Task3 plays an important role in the adaptation of aldosterone secretion to dietary salt intake. (Endocrinology 153: 4740-4748, 2012)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLOOD-PRESSURE; ALDOSTERONE SECRETION; GLOMERULOSA CELLS; ADRENAL-CORTEX; K+ CHANNEL; METAANALYSIS; CONDUCTANCE; EXPRESSION; MUTATIONS; VARIANTS; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Richard Warth Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2020 07:03 |
| Last Modified: | 06 May 2020 07:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18043 |
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