Heller, Anne and Brockhoff, Gero and Goepferich, Achim (2012) Targeting drugs to mitochondria. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 82 (1). pp. 1-18. ISSN 0939-6411, 1873-3441
Full text not available from this repository. (Request a copy)Abstract
Mitochondria are of an increasing interest in pharmaceutical and medical research since it has been reported that dysfunction of these organelles contributes to several diseases with a great diversity of clinical appearance. By the fact that mitochondria are located inside the cell and, in turn, origins of mitochondrial diseases or targets of drugs are located inside mitochondria, a drug molecule has to cross several barriers. This is a severe drawback for the selective accumulation of drug molecules in mitochondria. Therefore, targeting strategies such as direct drug modification or encapsulation into nanocarriers have to be applied to achieve an accumulation of drug molecules in these organelles. In this review, it will be demonstrated how properties and dysfunctions of mitochondria are generating a need for the development of mitochondria specific therapies. Furthermore, intracellular targets of mitochondrial diseases, strategies to utilize mitochondrial specificities and targeting approaches will be discussed. Finally, techniques to investigate mitochondrial characteristics and functionality are reviewed. (c) 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER-THERAPY; FLOW-CYTOMETRY; PROTEIN IMPORT; IN-VITRO; PENETRATING PEPTIDES; DNA MUTATIONS; CELL-DEATH; ANTICANCER THERAPY; ALZHEIMERS-DISEASE; MAMMALIAN SIRTUINS; Intracellular targeting; Mitochondria; Drug delivery; Targeting strategies; Nanocarriers; Mitochondrial diseases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 22 May 2020 09:52 |
| Last Modified: | 22 May 2020 09:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18155 |
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