Roscigno, Marco and Cha, Eugene K. and Rink, Michael and Seitz, Christian and Novara, Giacomo and Chromecki, Thomas F. and Fritsche, Hans-Martin and Matsumoto, Kazumasa and Walton, Thomas J. and Carballido, Joaquin and Da Pozzo, Luigi Filippo and Bertini, Roberto and Ficarra, Vincenzo and Otto, Wolfgang and Karakiewicz, Pierre I. and Pycha, Armin and Fajkovic, Harun and Naspro, Richard and Scherr, Douglas S. and Montorsi, Francesco and Shariat, Shahrokh F. (2012) International validation of the prognostic value of subclassification for AJCC stage pT3 upper tract urothelial carcinoma of the renal pelvis. BJU INTERNATIONAL, 110 (5). pp. 674-681. ISSN 1464-4096,
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVE To externally validate the prognostic value of subclassification of pT3 renal pelvic upper tract urothelial carcinoma (UTUC) in a large international cohort of patients treated with radical nephroureterectomy (RNU). PATIENTS AND METHODS The RNU specimens with pT3 UTUC of the renal pelvis from 284 patients at 11 centres located in Asia, North America and Europe were retrospectively evaluated. All specimens were reviewed by genitourinary pathologists at each institution. Tumours were categorized as pT3a (microscopic infiltration of the renal parenchyma) or pT3b (macroscopic infiltration of the renal parenchyma and/or infiltration of peripelvic adipose tissue). RESULTS Overall, 148 (52%) tumours were classified as pT3a and 136 (48%) as pT3b. Patients with pT3b disease were more likely to have high-grade tumours and sessile tumour architecture (all P <= 0.02). Patients with pT3b tumours were at increased risk of disease recurrence (5-year estimates: 55% versus 42%, P = 0.012) and cancer-specific mortality (CSM) (5-year estimates: 48% versus 40%, P = 0.04). Lymph node status, tumour architecture and tumour grade were independently associated with disease recurrence, whereas lymph node status, tumour architecture and lymphovascular invasion were independently associated with CSM. Subclassification of pT3 tumours was not associated with recurrence or CSM in multivariable analyses. CONCLUSION Patients with pT3b UTUC were more likely to have tumours with aggressive pathological features and were at higher risk of disease recurrence and CSM after RNU compared with patients with pT3a disease. However, the pT3 subclassification did not remain an independent predictor of disease recurrence or CSM after controlling for tumour grade, lymph node status, tumour architecture and lymphovascular invasion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UPPER URINARY-TRACT; TRANSITIONAL-CELL CARCINOMA; RADICAL NEPHROURETERECTOMY; INVASION; OUTCOMES; IMPACT; LYMPHADENECTOMY; CLASSIFICATION; PREDICTOR; CANCER; urothelial carcinoma; upper urinary tract; prognosis; survival; TNM staging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2020 08:32 |
| Last Modified: | 06 May 2020 08:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18171 |
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