Patil, Rameshwar and Portilla-Arias, Jose and Ding, Hui and Konda, Bindu and Rekechenetskiy, Arthur and Inoue, Satoshi and Black, Keith L. and Holler, Eggehard and Ljubimova, Julia Y. (2012) Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(beta-L-Malic Acid). INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13 (9). pp. 11681-11693. ISSN 1422-0067,
Full text not available from this repository. (Request a copy)Abstract
Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery systems. However, a major drawback remains its toxicity to healthy tissue and the development of multi-drug resistance during prolonged treatment. This is why in our work we aimed to improve DOX delivery and reduce the toxicity by chemical conjugation with a new nanoplatform based on polymalic acid. For delivery into recipient cancer cells, DOX was conjugated via pH-sensitive hydrazone linkage along with polyethylene glycol (PEG) to a biodegradable, non-toxic and non-immunogenic nanoconjugate platform: poly(beta-L-malic acid) (PMLA). DOX-nanoconjugates were found stable under physiological conditions and shown to successfully inhibit in vitro cancer cell growth of several invasive breast carcinoma cell lines such as MDA-MB-231 and MDA-MB-468 and of primary glioma cell lines such as U87MG and U251.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIDRUG-RESISTANCE; TUMOR; EFFICACY; COPOLYMERS; MECHANISMS; GROWTH; polymalic acid; doxorubicin; nanoconjugate; pH-controlled hydrazine linkage; brain and breast cancer |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Alumni or Retired > Prof. Dr. Eggehard Holler |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2020 10:17 |
| Last Modified: | 06 May 2020 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18181 |
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