Palatzky, Peter and Matysik, Frank-Michael (2012) Development and characterization of a novel semiautomated arrangement for electrochemically assisted injection in combination with capillary electrophoresis time-of-flight mass spectrometry. ELECTROPHORESIS, 33 (17). pp. 2689-2694. ISSN 0173-0835,
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Electrochemically assisted injection (EAI) is an attractive injection concept for CE that enables the separation of neutral analytes via electrochemical generation of charged species during the injection process. A new semiautomated EAI configuration was developed and applied in conjunction with CE-MS (EAI-CE-MS). The EAI cell arrangement consists of an integrated buffer reservoir for CEseparations and a compartment holding screen-printed electrodes. A drop of sample solution (50 mu L) was sufficient to cover the three-electrode structures. A piezo motor provided a fast and precise capillary positioning over the screen-printed electrode assembly. Using ferrocene methanol as a model system, the EAI arrangement was characterized regarding coulometric efficiency, precision, and sensitivity of electrospray ionization-time-of-flight-MS. The formation of the cationic oxidation product of ferrocene methanol enhanced the sensitivity of CE-MS determination by two orders of magnitude and the electrochemically formed product showed a migration time corresponding to its individual electrophoretic mobility. Preliminary studies of EAI-CE-MS in the field of the analysis of nitroaromatic compounds were carried out. The formation of corresponding hydroxylamines and amines paved the way for selective and sensitive CE-MS determinations without the need of adding surfactants to the electrophoresis buffer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPLOSIVES; ELECTRODES; Capillary electrophoresis; Electrochemically assisted injection; Mass spectrometry; Mass voltammetry; Nitroaromatic compounds |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2020 08:50 |
| Last Modified: | 06 May 2020 08:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18191 |
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