Hilgendorf, Inken and Wolff, Daniel and Nogai, Axel and Kundt, Guenther and Hahn, Joachim and Holler, Ernst and Uharek, Lutz and Junghanss, Christian and Leithaeuser, Malte and Thiel, Eckhard and Freund, Mathias and Kahl, Christoph (2012) Chronic Graft versus Host Disease but not the Intensity of Conditioning Has Impact on Survival after Allogeneic Hematopoietic Stem Cell Transplantation for Advanced Hematological Diseases. ONKOLOGIE, 35 (9). pp. 487-492. ISSN 0378-584X,
Full text not available from this repository. (Request a copy)Abstract
Background: Allogeneic hematopoietic stem cell transplantation (alloHSCT) is often performed in cases of advanced hematological diseases, but because of the associated mortality and a high risk of relapse it is life prolonging only in some patients. Patients and Methods: A retrospective multi-center analysis of 401 patients was conducted to analyze the variables associated with outcome after alloHSCT in advanced hematological diseases. The Cox proportional hazards model was used to assess the independence of overall survival (OS) and disease-free survival (DFS) from prognostic factors in a multivariate model. Results: The 5-year OS and DFS were 27.3 and 21.1% respectively. Multivariate analysis showed that the underlying malignancy had a significant influence on OS and DFS (p < 0.001 and p < 0.011, respectively), whereas development of severe acute graft versus host disease (GvHD) had a negative impact on OS (p < 0.001). Development of chronic GvHD showed a trend to a better OS (p = 0.085) and DFS (p = 0.199). No impact was seen for the intensity of conditioning. Conclusion: Development of chronic GvHD but not the conditioning regimen improved the outcome after alloHSCT for advanced malignancies, underlining the importance of immunological rather than cytotoxic effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; TERM-FOLLOW-UP; RELAPSE; BLOOD; DONOR; RISK; Hematological malignancies, advanced; Allogeneic stem cell transplantation; Graft versus host disease, chronic; Myeloablative conditioning; Reduced intensity conditioning |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2020 08:38 |
| Last Modified: | 06 May 2020 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18206 |
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