Maisch, Tim and Shimizu, Tetsuji and Mitra, Anindita and Heinlin, Julia and Karrer, Sigrid and Li, Yang-Fang and Morfill, Gregor and Zimmermann, Julia L. (2012) Contact-free cold atmospheric plasma treatment of Deinococcus radiodurans. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 39 (9). pp. 1367-1375. ISSN 1367-5435, 1476-5535
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In this study we investigated the sensitivity of Deinococcus radiodurans to contact-free cold atmospheric plasma treatment as part of a project to establish new efficient procedures for disinfection of inanimate surfaces. The Gram-positive D. radiodurans is one of the most resistant microorganisms worldwide. Stationary phases of D. radiodurans were exposed to cold atmospheric plasma for different time intervals or to ultraviolet C (UVC) radiation at dose rates of 0.001-0.0656 J cm(-2), respectively. A methicillin-resistant Staphylococcus aureus strain (MRSA) served as control for Gram-positive bacteria. The surface microdischarge plasma technology was used for generation of cold atmospheric plasma. A plasma discharge was ignited using ambient air. Surprisingly, D. radiodurans was sensitive to the cold atmospheric plasma treatment in the same range as the MRSA strain. Survival of both bacteria decreased with increasing plasma exposure times up to 6 log(10) cycles (> 99.999 %) within 20 s of plasma treatment. In contrast, UVC radiation of both bacteria demonstrated that D. radiodurans was more resistant to UVC treatment than MRSA. Cold atmospheric plasma seems to be a promising tool for industrial and clinical purposes where time-saving is a critical point to achieve efficient disinfection of inanimate surfaces and where protection from corrosive materials is needed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RADIATION-RESISTANCE; OXIDATIVE STRESS; GAMMA-RADIATION; SP NOV.; SURVIVAL; RADIORESISTANCE; ASSOCIATION; MEMBRANE; BACTERIA; MN(II); Rapid inactivation; Deinococcus radiodurans; MRSA; Ambient plasma; Reactive species; Oxidative burst |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2020 08:54 |
| Last Modified: | 06 May 2020 08:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18213 |
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