Seok, Young Mi and Jang, Eun Jin and Reiser, Oliver and Hager, Markus and Kim, In Kyeom (2012) 17 beta-Estradiol induces vasorelaxation in a G-protein-coupled receptor 30-independent manner. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 385 (9). pp. 945-948. ISSN 0028-1298,
Full text not available from this repository. (Request a copy)Abstract
17 beta-Estradiol (E2) exerts rapid non-genomic vascular effects through activation of its plasma membrane receptors. We tested the hypothesis that E2 induces vasorelaxation through activation of the G-protein-coupled receptor 30 (GPR30) in rat aorta. Rat aortic rings were mounted in organ baths and subjected to contraction followed by relaxation. Whether endothelium was intact or denuded, both E2 and G1, a GPR30 agonist, induced vasorelaxation in concentration-dependent manners. Although G15, a specific GPR30 antagonist, blocked G1-induced vasorelaxation, it did not block E2-induced vasorelaxation. In conclusion, 17 beta-estradiol induces vasorelaxation in a GPR30-independent manner in rat aorta.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATTENUATES VASCULAR CONTRACTION; ESTROGEN-RECEPTOR; PLASMA-MEMBRANE; ESTRADIOL; ALPHA; GPR30; ENDOTHELIUM; ARTERIES; BETA; INHIBITION; 17 beta-Estradiol; G-protein-coupled receptor 30 (GPR30); Vasorelaxation; G1; G15 |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2020 05:10 |
| Last Modified: | 07 May 2020 05:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18251 |
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