Nguyen, Le-Thu T. and Nguyen, Hieu T. and Barbic, Matej and Brunner, Gabi and Heilmann, Joerg and Pham, Hung D. and Nguyen, Duc M. and Nguyen, Lien-Hoa D. (2012) Polyisoprenylated acylphloroglucinols and a polyisoprenylated tetracyclic xanthone from the bark of Calophyllum thorelii. TETRAHEDRON LETTERS, 53 (34). pp. 4487-4493. ISSN 0040-4039,
Full text not available from this repository. (Request a copy)Abstract
Two new polyisoprenylated acylphloroglucinols, thoreliones A and B, and a new polyisoprenylated tetracyclic xanthone, oxy-thorelione A, together with twelve known compounds, were isolated from the bark of Calophyllum thorelii. The new structures were determined using spectroscopic methods and chemical modification. The major compound thorelione A (1) showed moderate cytotoxic activity against MCF-7. HeLa and NCl-H460 cells with IC50 values of 7.4, 9.3 and 10.6 mu g/mL, respectively, using the sulforhodamine B assay. (c) 2012 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RADICAL REACTION-PRODUCTS; BENZOYLPHLOROGLUCINOL DERIVATIVES; BENZOPHENONE DERIVATIVES; ANTIOXIDANT MECHANISM; SYMPHONIA-GLOBULIFERA; ANTITUMOR ACTIVITIES; CYTOTOXICITY; CHEMISTRY; GARCINOL; ASSAYS; Calophyllum thorelii; Guttiferae; Polyisoprenylated acylphloroglucinols; Cytotoxicity |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2020 05:47 |
| Last Modified: | 07 May 2020 05:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18280 |
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