Reiter, Alarich and Hamperl, Stephan and Seitz, Hannah and Merkl, Philipp and Perez-Fernandez, Jorge and Williams, Lydia and Gerber, Jochen and Nemeth, Attila and Leger, Isabelle and Gadal, Olivier and Milkereit, Philipp and Griesenbeck, Joachim and Tschochner, Herbert (2012) The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast. EMBO JOURNAL, 31 (16). pp. 3480-3493. ISSN 0261-4189, 1460-2075
Full text not available from this repository. (Request a copy)Abstract
Several DNA cis-elements and trans-acting factors were described to be involved in transcription termination and to release the elongating RNA polymerases from their templates. Different models for the molecular mechanism of transcription termination have been suggested for eukaryotic RNA polymerase I (Pol I) from results of in vitro and in vivo experiments. To analyse the molecular requirements for yeast RNA Pol I termination, an in vivo approach was used in which efficient termination resulted in growth inhibition. This led to the identification of a Myb-like protein, Ydr026c, as bona fide termination factor, now designated Nsi1 (NTS1 silencing protein 1), since it was very recently described as silencing factor of ribosomal DNA. Possible Nsi1 functions in regard to the mechanism of transcription termination are discussed. The EMBO Journal (2012) 31, 3480-3493. doi:10.1038/emboj.2012.185; Published online 17 July 2012
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRE-RIBOSOMAL-RNA; FACTOR TTF-I; TERNARY TRANSCRIPTION COMPLEXES; SACCHAROMYCES-CEREVISIAE; BINDING-PROTEIN; GLOBAL ANALYSIS; POLY(A) SIGNAL; BUDDING YEAST; RDNA REPEATS; 3' END; nucleolus; ribosome biogenesis; rRNA synthesis; transcription termination; TTF-I |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Herbert Tschochner Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Dr. Joachim Griesenbeck Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Dr. Philipp Milkereit |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 05:14 |
| Last Modified: | 11 May 2020 05:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18294 |
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