Schrader, Alexandra and Bentink, Stefan and Spang, Rainer and Lenze, Dido and Hummel, Michael and Kuo, Michael and Arrand, John R. and Murray, Paul G. and Truemper, Lorenz and Kube, Dieter and Vockerodt, Martina (2012) High myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas. INTERNATIONAL JOURNAL OF CANCER, 131 (4). E348-E361. ISSN 0020-7136,
Full text not available from this repository. (Request a copy)Abstract
Gene expression profiling has recently enabled the reclassification of aggressive non-Hodgkin lymphomas (aNHL) into distinct subgroups. In Burkitt lymphoma (BL) aberrant c-Myc activity results from IG-MYC translocations. However, MYC aberrations are not limited to BLs and then have a negative prognostic impact. In this study, we investigated to which extent aberrant c-Myc activity plays a functional role in other aNHL and whether it is independent from MYC translocations. Based on a combined microarray analysis of human germinal center (GC) B cells transfected with c-Myc and 220 aNHLs cases, we developed a c-Myc index. This index measures the extent to which lymphomas express c-Myc responsive genes. It comprises genes that are affected in a variety of tumors compared to normal tissue. This supports the view that aberrant c-Myc expression in GC B cells triggers a tumor-like expression pattern. As expected, the c-Myc index is very high in molecular Burkitt lymphoma (mBL), but more importantly also high within other aNHL. It constitutes a negative prognostic marker independent of established risk factors and of the presence of a MYC translocation. Our data provide new insights into the role of c-Myc activity in different lymphomas and raises the question of treatment changes for those patients under risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; LATENT MEMBRANE PROTEIN-1; BARR-VIRUS ONCOPROTEIN; C-MYC; BURKITTS-LYMPHOMA; CHROMOSOMAL TRANSLOCATIONS; TRANSCRIPTIONAL REPRESSION; ACTIVATION; EXPRESSION; PATHWAY; c-Myc; germinal center B cells; gene expression; index |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2020 06:24 |
| Last Modified: | 07 May 2020 06:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18297 |
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