Zillner, Karina and Nemeth, Attila (2012) Single-molecule, genome-scale analyses of DNA modifications: exposing the epigenome with next-generation technologies. EPIGENOMICS, 4 (4). pp. 403-414. ISSN 1750-1911, 1750-192X
Full text not available from this repository. (Request a copy)Abstract
DNA modifications represent an integral part of the epigenome and they have a pivotal role in regulation of genome function. Despite the wide variety of analytical techniques that have been developed to detect DNA modifications, their investigation at the single-genome level is only beginning to emerge. In contrast to population-averaged analyses, single-molecule approaches potentially allow the mapping of epigenetic linkage between distantly located genomic regions, the locus-specific ana-lysis of repetitive DNA elements, as well as determination of allele-specific DNA modification patterns. In this article, the properties of current single-molecule analyses of DNA modifications will be discussed and compared. In addition, the possible biomedical and discovery research applications of single-molecule epigenomics will be highlighted.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METHYLATION PATTERNS; REPETITIVE SEQUENCES; HUMAN-DISEASES; MAMMALIAN DNA; HUMAN CANCER; WIDE; 5-METHYLCYTOSINE; EPIGENETICS; BASE; 5-HYDROXYMETHYLCYTOSINE; 5-hydroxymethylcytosine; 5-methylcytosine; DNA combing; DNA methylation; epigenetic biomarkers; nanopore sequencing; repetitive DNA; SMRT sequencing |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > House of the Ribosome |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 May 2020 08:09 |
| Last Modified: | 18 May 2020 08:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18314 |
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