Eckert, Gunter P. and Renner, Kathrin and Eckert, Schamim H. and Eckmann, Janett and Hagl, Stephanie and Abdel-Kader, Reham M. and Kurz, Christopher and Leuner, Kristina and Muller, Walter E. (2012) Mitochondrial Dysfunction-A Pharmacological Target in Alzheimer's Disease. MOLECULAR NEUROBIOLOGY, 46 (1). pp. 136-150. ISSN 0893-7648, 1559-1182
Full text not available from this repository. (Request a copy)Abstract
Increasing evidences suggest that mitochondrial dysfunction plays an important role in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). Alterations of mitochondrial efficiency and function are mainly related to alterations in mitochondrial content, amount of respiratory enzymes, or changes in enzyme activities leading to oxidative stress, mitochondrial permeability transition pore opening, and enhanced apoptosis. More recently, structural changes of the network are related to bioenergetic function, and its consequences are a matter of intensive research. Several mitochondria-targeting compounds with potential efficacy in AD including dimebon, methylene blue, piracetam, simvastatin, Ginkgo biloba, curcumin, and omega-3 polyunsaturated fatty acids have been identified. The majority of preclinical data indicate beneficial effects, whereas most controlled clinical trials did not meet the expectations. Since mitochondrial dysfunction represents an early event in disease progression, one reason for the disappointing clinical results could be that pharmacological interventions might came too late. Thus, more studies are needed that focus on therapeutic strategies starting before severe disease progress.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GINKGO-BILOBA-EXTRACT; AMYLOID PRECURSOR PROTEIN; PERMEABILITY TRANSITION PORE; PYRUVATE-DEHYDROGENASE ACTIVITY; OXYGEN SPECIES PRODUCTION; N-TERMINAL KINASE; METHYLENE-BLUE; NITRIC-OXIDE; OXIDATIVE STRESS; BCL-2 FAMILY; Mitochondrial dysfunction; Alzheimer's disease; Neurodegenerative disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2020 04:56 |
| Last Modified: | 08 May 2020 04:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18329 |
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