Zayed, Gamal M. S. and Tessmar, Joerg K. V. (2012) Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting. MACROMOLECULAR BIOSCIENCE, 12 (8). pp. 1124-1136. ISSN 1616-5187,
Full text not available from this repository. (Request a copy)Abstract
Heterobifunctional poly(ethylene glycol)s can be used for many biomedical applications ranging from solubility enhancement of hardly soluble compounds to surface modification of medical devices. In order to modify gold nanoparticles as model particles for drug targeting applications, PEG derivatives are synthesized that possess a high affinity for gold surfaces, namely a thioalkyl function, known to form stable monolayers on gold. Additionally a bisphosphonate function is introduced in the PEG molecule to allow targeting of hydroxyapatite rich tissues, like bone. Gold nanoparticles are modified using the synthesized bifunctional PEG and investigated for their stability in biological fluids and their ability to bind to hydroxyapatite granules in these fluids.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; bisphosphonate; bone targeting; functionalization of polymers; nanoparticles; poly(ethylene glycol) |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2020 05:07 |
| Last Modified: | 08 May 2020 05:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18347 |
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