Rogenhofer, Sebastian and Ellinger, Joerg and Kahl, Philip and Stoehr, Christine and Hartmann, Arndt and Engehausen, Dirk and Wieland, Wolf-Ferdinand and Mueller, Stefan C. and Hofstaedter, Ferdinand and Walter, Bernhard (2012) Enhanced Expression of Peroxisome Proliferate-activated Receptor Gamma (PPAR-gamma) in Advanced Prostate Cancer. ANTICANCER RESEARCH, 32 (8). pp. 3479-3483. ISSN 0250-7005,
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Background: Recent studies have underlined the role of nuclear receptors in the involvement of prostate cancer signalling pathways. Patients and Methods: A total of 84 benign prostate hyperplasia (BPH), 84 low risk prostate cancer (LPC) and 64 advanced disease (APC) cases were sampled on a tissue microarray (TMA) and stained for retinoic acid receptor (RAR)-alpha, retionoid X receptor (RXR)-alpha, liver X receptor (LXR)-alpha, farnesoid X receptor (FXR) and proliferate-activated receptor gamma (PPAR)-gamma and the (pro)-inflammatory molecules cyclooxygenase 2 (COX2), tumor necrosis factor (TNF)-alpha and inducible Nitric oxide synthase (iNOS) immunohistochemically. Results: PPAR-gamma expression in APC tissues was found to be significantly higher than that in LPC and BPH specimens (p<0.001). In contrast, RXR-a expression was significantly lower (p<0.001). COX2 staining demonstrated a trend towards overexpression in APC (p=0.025). No significant differences were found for RAR-alpha, iNOS and TNF-alpha expression. Staining of FXR and LYR was seen diffusely in the cytoplasm as well as in the nucleus, preventing sufficient evaluation by definition. Conclusion: This study provides the basis for applying PPAR-gamma ligands clinically in treatment of APC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NUCLEAR RECEPTORS; CYCLOOXYGENASE-2; INFLAMMATION; MODULATION; DOCETAXEL; ESTROGEN; ANDROGEN; ALPHA; Prostate cancer; inflammation; nuclear receptor PPAR-gamma; immunohistochemistry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2020 05:50 |
| Last Modified: | 08 May 2020 05:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18361 |
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