Landgrebe, Michael and Azevedo, Andreia and Baguley, David and Bauer, Carol and Cacace, Anthony and Coelho, Claudia and Dornhoffer, John and Figueiredo, Ricardo and Flor, Herta and Hajak, Goeran and van de Heyning, Paul and Hiller, Wolfgang and Khedr, Eman and Kleinjung, Tobias and Koller, Michael and Lainez, Jose Miguel and Londero, Alain and Martin, William H. and Mennemeier, Mark and Piccirillo, Jay and De Ridder, Dirk and Rupprecht, Rainer and Searchfield, Grant and Vanneste, Sven and Zeman, Florian and Langguth, Berthold (2012) Methodological aspects of clinical trials in tinnitus: A proposal for an international standard. JOURNAL OF PSYCHOSOMATIC RESEARCH, 73 (2). pp. 112-121. ISSN 0022-3999,
Full text not available from this repository. (Request a copy)Abstract
Chronic tinnitus is a common condition with a high burden of disease. While many different treatments are used in clinical practice, the evidence for the efficacy of these treatments is low and the variance of treatment response between individuals is high. This is most likely due to the great heterogeneity of tinnitus with respect to clinical features as well as underlying pathophysiological mechanisms. There is a clear need to find effective treatment options in tinnitus, however, clinical trials differ substantially with respect to methodological quality and design. Consequently, the conclusions that can be derived from these studies are limited and jeopardize comparison between studies. Here, we discuss our view of the most important aspects of trial design in clinical studies in tinnitus and make suggestions for an international methodological standard in tinnitus trials. We hope that the proposed methodological standard will stimulate scientific discussion and will help to improve the quality of trials in tinnitus. (c) 2012 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; PSYCHOMETRIC PROPERTIES; BEHAVIORAL-THERAPY; RANDOMIZED TRIALS; CONSORT STATEMENT; AUDITORY-CORTEX; TREAT TINNITUS; SENSATION; GABAPENTIN; COMPLEXITY; Tinnitus; Clinical trials; Trial methodology; Guideline |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2020 06:08 |
| Last Modified: | 08 May 2020 06:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18396 |
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