Broichhausen, Christiane and Riquelme, Paloma and Geissler, Edward K. and Hutchinson, James A. (2012) Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation. CURRENT OPINION IN ORGAN TRANSPLANTATION, 17 (4). pp. 332-342. ISSN 1087-2418
Full text not available from this repository. (Request a copy)Abstract
Purpose of review This review aims to provide a basic introduction to human macrophage biology and an appreciation of the diverse roles played by macrophage subsets in allograft damage and repair. Current and future strategies for therapeutically manipulating macrophage behaviour are discussed. Recent findings Macrophages are extremely versatile effector cells that exert both immunostimulatory and immunosuppressive effects. This adaptability cannot be explained by differentiation into committed sublineages, but instead reflects the ability of macrophages to rapidly transition between states of functional polarisation. Consequently, categorisation of macrophage subpopulations is not straightforward and this, in turn, creates difficulties in studying their pathophysiology. Nevertheless, particular macrophage subpopulations have been implicated in exacerbating or attenuating ischaemia-reperfusion injury, rejection reactions and allograft fibrosis. Three general strategies for therapeutically targeting macrophages can be envisaged, namely, depletional approaches, in-situ repolarisation towards a regulatory or tissue-reparative phenotype, and ex-vivo generation of regulatory macrophages (M reg) as a cell-based therapy. Summary As critical determinants of the local and systemic immune response to solid organ allografts, macrophage subpopulations represent attractive therapeutic targets. Rapid progress is being made in the implementation of novel macrophage-targeted therapies, particularly in the use of ex-vivo-generated M regs as a cell-based medicinal product.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ISCHEMIA-REPERFUSION INJURY; RENAL-ALLOGRAFT REJECTION; ACCEPTANCE-INDUCING-CELLS; ANTIGEN-PRESENTING CELLS; HUMAN PERIPHERAL-BLOOD; STIMULATING FACTOR-I; ACUTE KIDNEY INJURY; DENDRITIC CELLS; T-CELLS; SUPPRESSOR-CELLS; cell-based medicinal product; M reg; regulatory macrophage; the ONE study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 May 2020 07:28 |
| Last Modified: | 18 May 2020 07:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18402 |
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