Engel, J. B. and Schally, A. V. and Buchholz, S. and Seitz, S. and Emons, G. and Ortmann, O. (2012) Targeted chemotherapy of endometrial, ovarian and breast cancers with cytotoxic analogs of luteinizing hormone-releasing hormone (LHRH). ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 286 (2). pp. 437-442. ISSN 0932-0067,
Full text not available from this repository. (Request a copy)Abstract
Receptors luteinizing hormone-releasing hormone (LHRH) are expressed in about 80 % of human endometrial and ovarian cancers and account for more than 50 % of breast cancers including triple negative breast cancers. Apart from the pituitary and reproductive organs, no other organs or hematopoietic stem cells express LHRH (GnRH) receptors. Thus, these receptors can be regarded as an ideal target for a personalized medicine approach in cancer therapy. AEZS-108 (formerly known as AN-152) in which doxorubin is linked to the LHRH agonist [d-Lys(6)]LHRH, appears to be the most advanced compound in late stage clinical development. Results of phase I and phase II clinical trials in patients with gynecological cancers demonstrated anticancer activity without any cardiotoxicity even in highly pretreated patients. AEZS-108 is therefore being considered for phase II trials in triple negative breast cancers and phase III studies in advanced endometrial cancers positive for LHRH-receptor. EP-100 is a membrane-disrupting peptide targeted to LHRH receptors, which is undergoing early clinical studies in ovarian cancer patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPIDERMAL-GROWTH-FACTOR; RECEPTOR-POSITIVE TUMORS; HIGH-AFFINITY BINDING; CELL-LINES; NUDE-MICE; PEPTIDE-HORMONES; AEZS-108 AN-152; DOXORUBICIN; SOMATOSTATIN; THERAPY; LHRH receptor-positive cancers; Targeted chemotherapy; Breast cancer; Ovarian cancer; Endometrial cancer; AEZS-108; Doxorubicin; EP-100 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2020 05:32 |
| Last Modified: | 08 May 2020 05:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18406 |
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