Kunzelmann, Karl and Schreiber, Rainer (2012) Airway epithelial cells-Hyperabsorption in CF? INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 44 (8). pp. 1232-1235. ISSN 1357-2725, 1878-5875
Full text not available from this repository. (Request a copy)Abstract
Airway epithelial cells transport electrolytes and are central to the disease cystic fibrosis (CF), which is an inherited transport defect affecting smaller airways and a number of other epithelial organs. Clinically, CF is dominated by a chronic lung disease, the main cause of morbidity and mortality. Airway obstruction by thick mucus and chronic infection by Pseudomonas aeruginosa eventually lead to loss of pulmonary function. Loss of function of CFTR Cl- channels was found to be the cause for CF. However, intensive research on the detailed mechanism of CF lung disease for more than 25 years produced a bewildering number of hypotheses and an endless discussion whether reduced Cl- secretion, primarily located in airway submucosal glands, or dehydration of the airways, driven by a hyperabsorption of Na+ ions, is the primary cause of the disease. Recent results suggest a fine-tuned regulation of the airway fluid layer, but how significant really are Cl- and Na+ transport? (C) 2012 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSMEMBRANE CONDUCTANCE REGULATOR; CYSTIC-FIBROSIS; SURFACE DEHYDRATION; NA+ CONDUCTANCE; INFLAMMATION; INHIBITION; MECHANISMS; TRANSPORT; DISEASE; COLON; Cystic fibrosis; ENaC; Na+ hyperabsorption; Airways; CFTR |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2020 05:39 |
| Last Modified: | 08 May 2020 05:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18409 |
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