Kuphal, Silke and Bosserhoff, Anja Katrin (2012) E-cadherin cell-cell communication in melanogenesis and during development of malignant melanoma. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 524 (1). pp. 43-47. ISSN 0003-9861, 1096-0384
Full text not available from this repository. (Request a copy)Abstract
Cell-cell communication is necessary for the crosstalk between cells that constitute multicellular organisms and is essential for cells to coordinate their physiological behavior to create cohesive tissues. Cellular crosstalk is not only controlled by molecules, like growth factors, hormones, ions and G-proteins, etc. but also by cell-cell contacts. These contacts are essential for intercellular communication and are involved in survival, apoptosis, proliferation, differentiation and homeostasis of entire tissues. In polarized epithelia of vertebrates, the adherent junction is part of the tripartite junctional complex that is localized at the juxtaluminal region, which includes tight junctions (including claudins, occludins, and zonula occludens proteins), desmosomal junctions (including desmogleins), and adherent junctions. In focus of the manuscript are adherent molecules of the cadherin superfamily of the skin. In the normal epidermis, melanocytes and keratinocytes are mostly connected via E-cadherin, P-cadherin and H-cadherin [1-3]. Melanocytes that reside in the basal layer of the epidermis predominantly contain E-cadherin and H-cadherin, whereas those that reside in the hair follicles are rich in P-cadherin [2]. The regulation and role of E-cadherin during melanoma development will be the focus of this review. (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEURAL CREST; N-CADHERIN; MESENCHYMAL TRANSITION; ADHESION MOLECULES; MELANOCYTIC TUMORS; MOUSE EMBRYOS; EXPRESSION; MIGRATION; INVASION; TRANSFORMATION; Cadherins; Melanoma; Snail; AP1; Signaling; Cell-cell contact |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 May 2020 06:58 |
| Last Modified: | 18 May 2020 06:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18416 |
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