Stankova, Trayana and Eichhammer, Peter and Langguth, Berthold and Sand, Philipp G. (2012) Sexually dimorphic effects of oxytocin receptor gene (OXTR) variants on Harm Avoidance. BIOLOGY OF SEX DIFFERENCES, 3: 17. ISSN 2042-6410,
Full text not available from this repository. (Request a copy)Abstract
Background: Recent research has suggested that oxytocin receptor gene (OXTR) variants may account for individual differences in social behavior, the effects of stress and parenting styles. Little is known, however, on a putative role of the gene in heritable temperamental traits. Methods: We addressed effects of two common OXTR variants, rs237900 and rs237902, on personality dimensions in 99 healthy subjects using the Temperament and Character Inventory. Results: When sex was controlled for and an OXTR genotype*sex interaction term was included in the regression model, 11% of the variance in Harm Avoidance could be explained (uncorrected p <= 0.01). Female carriers of the minor alleles scored highest, and a novel A217T mutation emerged in the most harm avoidant male participant. Conclusions: Findings lend support to a modulatory effect of common OXTR variants on Harm Avoidance in healthy caucasian women and invite resequencing of the gene in anxiety phenotypes to identify more explanatory functional variation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 05:37 |
| Last Modified: | 11 May 2020 05:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18424 |
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