Weider, Matthias and Kuespert, Melanie and Bischof, Melanie and Vogl, Michael R. and Hornig, Julia and Loy, Kristina and Kosian, Thomas and Mueller, Jana and Hillgaertner, Simone and Tamm, Ernst R. and Metzger, Daniel and Wegner, Michael (2012) Chromatin-Remodeling Factor Brg1 Is Required for Schwann Cell Differentiation and Myelination. DEVELOPMENTAL CELL, 23 (1). pp. 193-201. ISSN 1534-5807,
Full text not available from this repository. (Request a copy)Abstract
Schwann cells produce myelin sheaths and thereby permit rapid saltatory conductance in the vertebrate peripheral nervous system. Their stepwise differentiation from neural crest cells is driven by a defined set of transcription factors. How this is linked to chromatin changes is not well understood. Here we show that the glial transcription factor Sox10 functions in Schwann cells by recruiting Brg1-containing chromatin-remodeling complexes via Baf60a to regulatory regions of Oct6 and Krox20 genes. It thereby stimulates expression of these transcriptional regulators that then cooperate with Sox10 to convert immature into myelinating Schwann cells. The functional interaction between Sox10 and Brg1 is evident from gain- and loss-of-function studies, similar neuropathies in the corresponding mouse mutants, and an aggravated neuropathy in compound mutants. Our results demonstrate that the transcription factor-mediated recruitment of the chromatin-remodeling machinery to specific genomic loci is an essential driving force for Schwann cell differentiation and myelination.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEURAL CREST INDUCTION; OLIGODENDROCYTE PRECURSORS; TRANSCRIPTION FACTORS; PERIPHERAL-NERVE; SOX10; COMPLEX; EXPRESSION; PROTEINS; SURVIVAL; MAINTENANCE; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 05:44 |
| Last Modified: | 11 May 2020 05:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18434 |
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