Zill, Peter and Baghai, Thomas C. and Schuele, Cornelius and Born, Christoph and Fruestueck, Clemens and Buettner, Andreas and Eisenmenger, Wolfgang and Varallo-Bedarida, Gabriella and Rupprecht, Rainer and Moeller, Hans-Juergen and Bondy, Brigitta (2012) DNA Methylation Analysis of the Angiotensin Converting Enzyme (ACE) Gene in Major Depression. PLOS ONE, 7 (7): e40479. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Background: The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD). In this context, functional polymorphisms of the ACE gene have been linked to depression, to antidepressant treatment response, to ACE serum concentrations, as well as to hypertension, myocardial infarction and CVD risk markers. The mostly investigated ACE Ins/Del polymorphism accounts for similar to 40%-50% of the ACE serum concentration variance, the remaining half is probably determined by other genetic, environmental or epigenetic factors, but these are poorly understood. Materials and Methods: The main aim of the present study was the analysis of the DNA methylation pattern in the regulatory region of the ACE gene in peripheral leukocytes of 81 MD patients and 81 healthy controls. Results: We detected intensive DNA methylation within a recently described, functional important region of the ACE gene promoter including hypermethylation in depressed patients (p = 0.008) and a significant inverse correlation between the ACE serum concentration and ACE promoter methylation frequency in the total sample (p = 0.02). Furthermore, a significant inverse correlation between the concentrations of the inflammatory CVD risk markers ICAM-1, E-selectin and P-selectin and the degree of ACE promoter methylation in MD patients could be demonstrated (p = 0.01 - 0.04). Conclusion: The results of the present study suggest that aberrations in ACE promoter DNA methylation may be an underlying cause of MD and probably a common pathogenic factor for the bi-directional relationship between MD and cardiovascular disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BRAIN RENIN-ANGIOTENSIN; INSERTION/DELETION POLYMORPHISM; PSYCHIATRIC-DISORDERS; EPIGENETIC REGULATION; MATERNAL-CARE; COMT PROMOTER; SYSTEM; EXPRESSION; RECEPTOR; DISEASE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 09:27 |
| Last Modified: | 11 May 2020 09:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18446 |
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