Braeckman, Tessa and Van Herck, Koen and Jilg, Wolfgang and Bauer, Tanja and Van Damme, Pierre (2012) Two decades of hepatitis B vaccination in mentally retarded patients: Effectiveness, antibody persistence and duration of immune memory. VACCINE, 30 (32). pp. 4757-4761. ISSN 0264-410X,
Full text not available from this repository. (Request a copy)Abstract
Introduction: Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18-20 years after the first vaccine dose. Materials and methods: Non-immune residents of 4 institutions were immunized in 1984-1986. In 2004, 207 subjects were bled to determine humoral and cellular immune memory. Immune response to a booster dose was evaluated in subjects with anti-HBs level <100 IU/L. Results: Four subjects showed anti-HBc seroconversion, without clinical implications. Pre-booster anti-HBs levels <100 IU/L were found in 45 subjects (22%); 34/39 (87%) responded with a rapid and high anti-HBs titer to the booster dose. Robust land B cell memory was present pre- and post-booster. Discussion and conclusion: Overall results confirm that hepatitis B vaccines are highly effective and immunogenic, and confer long-term persistence of antibodies and immune memory in an at-risk population. (C) 2012 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSTITUTIONS; INDIVIDUALS; ANTIGEN; VIRUS; Hepatitis B virus; Immunization; Immune memory; Effectiveness; Humoral immunity; Cellular immunity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 06:06 |
| Last Modified: | 11 May 2020 06:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18457 |
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