Wrobel, Matthias and Aube, Jeffrey and Koenig, Burkhard (2012) Parallel solid-phase synthesis of diaryltriazoles. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 8. pp. 1027-1036. ISSN 1860-5397,
Full text not available from this repository. (Request a copy)Abstract
A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein-protein interactions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-PROTEIN INTERACTIONS; CLICK CHEMISTRY; ALPHA-HELIX; DESIGN; PEPTIDOMIMETICS; CYCLOADDITION; ANTAGONISTS; MECHANISM; MIMETICS; chemical diversity; Huisgen cycloaddition; library synthesis; peptidomimetics; solid phase synthesis; triazole |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 06:08 |
| Last Modified: | 11 May 2020 06:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18458 |
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