Thome, Johannes and Ehlis, Ann-Christine and Fallgatter, Andreas J. and Krauel, Kerstin and Lange, Klaus W. and Riederer, Peter and Romanos, Marcel and Taurines, Regina and Tucha, Oliver and Uzbekov, Marat and Gerlach, Manfred (2012) Biomarkers for attention-deficit/hyperactivity disorder (ADHD). A consensus report of the WFSBP task force on biological markers and the World Federation of ADHD. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 13 (5). pp. 379-400. ISSN 1562-2975, 1814-1412
Full text not available from this repository. (Request a copy)Abstract
Objective. Psychiatric "nosology" is largely based on clinical phenomenology using convention-based diagnostic systems not necessarily reflecting neurobiological pathomechanisms. While progress has been made regarding its molecular biology and neuropathology, the phenotypic characterization of ADHD has not improved. Thus, validated biomarkers, more directly linked to the underlying pathology, could constitute an objective measure for the condition. Method. The task force on biological markers of the World Federation of Societies of Biological Psychiatry (WFSBP) and the World Federation of ADHD commissioned this paper to develop a consensus report on potential biomarkers of ADHD. The criteria for biomarker-candidate evaluation were: (1) sensitivity >80%, (2) specificity >80%, (3) the candidate is reliable, reproducible, inexpensive, non-invasive, easy to use, and (4) confirmed by at least two independent studies in peer-reviewed journals conducted by qualified investigators. Results. No reliable ADHD biomarker has been described to date, but some promising candidates (e. g., olfactory sensitivity, substantial echogenicity) exist. A problem in the development of ADHD markers is sample heterogeneity due to aetiological and phenotypic complexity and age-dependent co-morbidities. Conclusions. Most likely, no single ADHD biomarker can be identified. However, the use of a combination of markers may help to reduce heterogeneity and to identify homogeneous subtypes of ADHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEFICIT-HYPERACTIVITY DISORDER; FUNCTIONAL MAGNETIC-RESONANCE; NEUROPSYCHOLOGICAL TEST-PERFORMANCE; OBSESSIVE-COMPULSIVE DISORDER; ANTERIOR CINGULATE FUNCTION; NEAR-INFRARED SPECTROSCOPY; OSTERRIETH COMPLEX FIGURE; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; WORKING-MEMORY; Biomarker; attentention-deficit/hyperactivity disorder; olfaction; transcranial echosonography; neuroimaging; proteomics |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 06:54 |
| Last Modified: | 11 May 2020 06:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18475 |
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