Buergers, Ralf and Witecy, Corinna and Hahnel, Sebastian and Gosau, Martin (2012) The effect of various topical peri-implantitis antiseptics on Staphylococcus epidermidis, Candida albicans, and Streptococcus sanguinis. ARCHIVES OF ORAL BIOLOGY, 57 (7). pp. 940-947. ISSN 0003-9969,
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Objective: Although peri-implantitis has presented an ever increasing problem in modem dentistry, satisfying therapeutic strategies or scientifically based treatment recommendations are still not available. The main object of the present study was to evaluate the antibacterial efficacy of six different topical antiseptics on three test microorganisms attached to titanium implant specimens. Material and methods: For biofilm formation, plane titan specimens were incubated either in Candida albicans, Streptococcus sanguinis, or Staphylococcus epidermidis for 2 h. The specimens were then treated with different topical antiseptics for 60s (sodium hypochlorite 1.0%, hydrogen peroxide 3.0%, chlorhexidine gluconate 0.2%, citric acid 40.0%, Flax, or Listerine) and with sterile saline as control. Remaining vital fungi were quantified by means of a bioluminometric assay and the bacterial load and the viability of adhering S. epidermidis and S. sanguinis by live or dead cell labelling in combination with fluorescence microscopy. Results: Sodium hypochlorite was effective against all three species, whereas hydrogen peroxide was solely effective against C. albicans. CHX and Listerine showed antimicrobial activity against S. sanguinis and C. albicans and citric acid and Plax against both tested bacteria. Conclusions: None of the tested antimicrobial agents, except for sodium hypochlorite, showed a significant in vitro effect on all three test microbes. Considering the possible toxicity of sodium hypochlorite, none of the tested - and so far widely used - antiseptics showed any broad-spectrum antimicrobial effect and could therefore not be recommended for the topical disinfection and detoxification of infected implant surfaces. (C) 2012 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MATERIALS IN-VIVO; NONSURGICAL TREATMENT; BIOFILM FORMATION; SODIUM-HYPOCHLORITE; BACTERIAL ADHESION; PLAQUE-FORMATION; DENTAL IMPLANTS; THERAPY; PERIODONTITIS; INFECTIONS; Antimicrobial agent; Implant surface; Oral bacteria; Peri-implantitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Zahnärztliche Prothetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 11:12 |
| Last Modified: | 11 May 2020 11:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18497 |
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