Moser, Christian and Lang, Sven A. and Hackl, Christina and Wagner, Christine and Scheiffert, Eva and Schlitt, Hans J. and Geissler, Edward K. and Stoeltzing, Oliver (2012) Targeting HSP90 by the Novel Inhibitor NVP-AUY922 Reduces Growth and Angiogenesis of Pancreatic Cancer. ANTICANCER RESEARCH, 32 (7). pp. 2551-2561. ISSN 0250-7005, 1791-7530
Full text not available from this repository. (Request a copy)Abstract
Aim: To evaluate the impact of heat-shock protein 90 (HSP90) blockade by the novel inhibitor NVP-AUY922, on tumor growth and angiogenesis in pancreatic cancer. Materials and Methods: Effects of NVP-AUY922 on signaling pathways were evaluated by western blotting. Cell motility of cancer cells, pericytes and endothelial cells was investigated in Boyden chambers. Impact of HSP90 blockade on pancreatic tumor growth and angiogenesis were studied in in vivo tumor models. Results: NVP-AUY922 effectively inhibited cancer cell growth. Moreover, HSP90 inhibition potently interfered with multiple signaling pathways in cancer cells, as well as endothelial cells and pericytes, leading to significant reduction of pro-migratory and invasive properties of these cell types. In vivo, treatment with NVP-AUY922 significantly inhibited growth and vascularization of pancreatic cancer at doses far below the maximum tolerated dose. Conclusion: HSP90 blockade by the novel synthetic inhibitor NVP-AUY922 effectively reduces pancreatic cancer progression through direct effects on cancer cells, as well as on endothelial cells and pericytes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORTHOTOPIC TUMOR-GROWTH; FACTOR RECEPTOR; ANTITUMOR-ACTIVITY; ENDOTHELIAL-CELLS; AUTOCRINE LOOP; PHASE-I; HEAT-SHOCK-PROTEIN-90; MIGRATION; SURVIVAL; MITOGEN; HSP90; pancreatic cancer; tumor growth; angiogenesis; NVP-AUY922; resorcinylic isoxazoles |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 May 2020 04:44 |
| Last Modified: | 12 May 2020 04:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18500 |
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