Decker, Michael and Holzgrabe, Ulrike (2012) M-1 muscarinic acetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease. MEDCHEMCOMM, 3 (7). pp. 752-762. ISSN 2040-2503
Full text not available from this repository. (Request a copy)Abstract
In this review the various chemical structures of allosteric agonists and modulators of the muscarinic acetylcholine receptor subtype 1 (mAChR(1) or M-1) and their relevance for possible treatment of Alzheimer's disease (AD) are discussed. Furthermore, their design principles, common structural properties and their unique features with regard to structure-activity relationships (SARs), such as 'molecular switches' and 'steep/flat' SARs, are highlighted. M-1 bitopic ligands and hybrid molecules are also considered. All these differently designed M-1 allosteric modulators open exciting new paths in medicinal chemistry with most promising therapeutic opportunities to fight AD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FUNCTIONAL SELECTIVITY; BIVALENT LIGANDS; AGONISTS AC-42; CNS PENETRANT; MUTANT MICE; DISCOVERY; ACTIVATION; DISORDERS; MECHANISM; DISTINCT; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 May 2020 05:56 |
| Last Modified: | 18 May 2020 05:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18524 |
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