Spangler, Barbara and Kappelmann, Melanie and Schittek, Birgit and Meierjohann, Svenja and Vardimon, Lily and Bosserhoff, Anja Katrin and Kuphal, Silke (2012) ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma. INTERNATIONAL JOURNAL OF CANCER, 130 (12). pp. 2801-2811. ISSN 0020-7136,
Full text not available from this repository. (Request a copy)Abstract
Recently, we discovered that the loss of E-cadherin induces c-Jun protein expression, which is a member of the AP-1 transcription factor family and a key player in the processes of cell proliferation and tumor development and also found in elevated levels in melanomas. Notably, the mRNA level of c-Jun was not affected, suggesting that c-Jun is regulated at post-transcriptional level. Here, we present data that suggest that the dynamic cytoskeletal network, linked to E-cadherin, is involved in the regulation of the c-Jun protein and transcriptional activity. In a signaling cascade, the loss of E-cadherin activates the transcriptional regulator ETS-1 and consequently leads to the induction of RhoC expression that stabilizes c-Jun in melanoma. The link between RhoC and c-Jun seems to be indirect via the cytoskeleton. We conclude that the loss of E-cadherin mediated cell-adhesion induces c-Jun protein expression in a multistep process, offering several possibilities for therapeutic intervention.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | E-CADHERIN; GLUCOCORTICOID-RECEPTOR; COLON-CARCINOMA; GENE-REGULATION; CELL-DENSITY; RHO GTPASES; CANCER; ACTIVATION; EXPRESSION; PATHWAY; c-Jun; melanoma; cytoskeleton; ETS-1; Rho |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2020 12:01 |
| Last Modified: | 11 May 2020 12:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18580 |
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