Schmid, Maximilian and Hunold, Katja and Weber-Steffens, Dorothea and Maennel, Daniela N. (2012) Ficolin-B marks apoptotic and necrotic cells. IMMUNOBIOLOGY, 217 (6). pp. 610-615. ISSN 0171-2985,
Full text not available from this repository. (Request a copy)Abstract
Ficolins are a group of proteins consisting of a fibrinogen-like and a collagen-like domain. They play a role in innate immunity by activating the complement system via the lectin pathway upon binding to carbohydrate patterns on pathogens. Two types of ficolins have been identified in mice, ficolin A and ficolin B (FcnB). We show in this article that recombinant FcnB binds to late apoptotic cells and to apoptotic bodies as well as to necrotic cells but not to early apoptotic cells. This binding was calcium-dependent and could be competitively inhibited by acetylated BSA, a classical binding substrate of FcnB. In addition, DNA inhibited binding of FcnB to apoptotic and necrotic cells, indicating that DNA exposed by dying cells could also be a ligand for FcnB. Thus, FcnB may play a role in the removal of damaged host cells and maintenance of tissue homeostasis. (C) 2011 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MANNOSE-BINDING LECTIN; H-FICOLIN; PROTEIN-D; INNATE; MOUSE; MACROPHAGES; MASP-2; VIVO; Apoptosis; Complement; DNA; Lectin pathway; Necrosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 May 2020 08:53 |
| Last Modified: | 12 May 2020 08:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18618 |
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