Maisch, Tim and Shimizu, Tetsuji and Isbary, Georg and Heinlin, Julia and Karrer, Sigrid and Klaempfl, Tobias G. and Li, Yang-Fang and Morfill, Gregor and Zimmermann, Julia L. (2012) Contact-Free Inactivation of Candida albicans Biofilms by Cold Atmospheric Air Plasma. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78 (12). pp. 4242-4247. ISSN 0099-2240, 1098-5336
Full text not available from this repository. (Request a copy)Abstract
Candida albicans is one of the main species able to form a biofilm on almost any surface, causing both skin and superficial mucosal infections. The worldwide increase in antifungal resistance has led to a decrease in the efficacy of standard therapies, prolonging treatment time and increasing health care costs. Therefore, the aim of this work was to demonstrate the applicability of atmospheric plasma at room temperature for inactivating C. albicans growing in biofilms without thermally damaging heat-sensitive materials. This so-called cold atmospheric plasma is produced by applying high voltage to accelerate electrons, which ionize the surrounding air, leading to the production of charged particles, reactive species, and photons. A newly developed plasma device was used, which exhibits a large plasma-generating surface area of 9 by 13 cm (117 cm(2)). Different time points were selected to achieve an optimum inactivation efficacy range of >= 3 log(10) to 5 log(10) reduction in CFU per milliliter, and the results were compared with those of 70% ethanol. The results obtained show that contact-free antifungal inactivation of Candida biofilms by cold atmospheric plasma is a promising tool for disinfection of surfaces (and items) in both health care settings and the food industry, where ethanol disinfection should be avoided.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIMICROBIAL PEPTIDES; STAPHYLOCOCCUS-AUREUS; PHOTODYNAMIC THERAPY; DISCHARGE PLASMA; DRUG-RESISTANCE; CHLORHEXIDINE; PERSPECTIVE; INFECTIONS; DEFENSINS; ADHERENCE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2020 05:14 |
| Last Modified: | 13 May 2020 05:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18650 |
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