Miller, Tobias and Hill, Alexandra and Uezguen, Senta and Weigandt, Markus and Goepferich, Achim (2012) Analysis of Immediate Stress Mechanisms upon Injection of Polymeric Micelles and Related Colloidal Drug Carriers: Implications on Drug Targeting. BIOMACROMOLECULES, 13 (6). pp. 1707-1718. ISSN 1525-7797, 1526-4602
Full text not available from this repository.Abstract
Polymeric micelles are ideal carriers for solubilization and targeting applications using hydrophobic drugs. Stability of colloidal aggregates upon injection into the bloodstream is mandatory to maintain the drugs' targeting potential and to influence pharmacokinetics. In this review we analyzed and discussed the most relevant stress mechanisms that polymeric micelles and related colloidal carriers encounter upon injection, including (1) dilution, (2) interactions with blood components, and (3) immunological responses of the body. In detail we analyzed the opsonin-dysopsonin hypothesis that points at a connection between a particles' protein-corona and its tissue accumulation by the enhanced permeability and retention (EPR) effect. In the established theory, size is seen as a necessary condition to reach nanoparticle accumulation in disease modified tissue. There is, however, mounting evidence of other sufficient conditions (e.g., particle charge, receptor recognition of proteins adsorbed onto particle surfaces) triggering nanoparticle extravasation by active mechanisms. In conclusion, the analyzed stress mechanisms are directly responsible for in vivo success or failure of the site-specific delivery with colloidal carrier systems.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACCELERATED BLOOD CLEARANCE; PROTEIN ADSORPTION PATTERNS; LIPOSOMAL DOXORUBICIN DOXIL; TUMOR-BEARING MICE; ACTIVATION-RELATED PSEUDOALLERGY; MOLECULAR-WEIGHT KININOGEN; SOLID-LIPID-NANOPARTICLES; ALBUMIN-BOUND PACLITAXEL; COMPLEMENT ACTIVATION; SERUM-PROTEINS; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 May 2020 10:06 |
| Last Modified: | 15 May 2020 10:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18651 |
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