de Buhr, Wiebke and Pfeifer, Stefan and Slotta-Huspenina, Julia and Wintermantel, Erich and Lutter, Georg and Goetz, Wolfgang A. (2012) Impairment of pericardial leaflet structure from balloon-expanded valved stents. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 143 (6). pp. 1417-1421. ISSN 0022-5223,
Full text not available from this repository. (Request a copy)Abstract
Objective: Malpositioning is one of the major problems in transcatheter aortic valve implantation. To evaluate the influence of mechanical balloon inflation on aortic valve stent positioning, the expansion process and the impact on the valve leaflet's structure were investigated. Methods: Custom-made stents were laser cut from a 22-mm diameter stainless steel tube and mounted with a glutaraldehyde-treated bovine pericardial valve. The valved stents were crimped onto a standard balloon catheter and expanded by inflation of the balloon with 2 bar for 3 seconds. Expansion was studied using a high-speed camera, and the histology of the pericardial tissue was analyzed. Results: The valved stents were fully expanded within 3 seconds. Balloon inflation was observed to be asymmetric starting proximally. At the beginning of expansion, the valved stents were pulled proximally. During further inflation, the stents slipped distally on the balloon and experienced a total displacement of 13.5 mm. Macroscopic examination showed severe imprinting of the stent struts into the pericardial tissue. Histology revealed disrupted tissue layers and collagen fibers. Conclusions: Analysis of valved stent expansion showed a displacement of the stent on the catheter during balloon inflation. Therefore, precise placement of the valved stent cannot be accomplished. Histologic analysis of the expanded pericardial tissue revealed disruption of collagen fibers. Disruption of pericardial tissue structures due to balloon expansion may result in early functional valve failure. (J Thorac Cardiovasc Surg 2012; 143: 1417-21)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AORTIC BIOPROSTHETIC VALVES; CALCIFICATION; IMPLANTATION; SUBSTITUTES; REPLACEMENT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2020 06:34 |
| Last Modified: | 13 May 2020 06:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18681 |
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