Lubig, Julia and Lattrich, Claus and Springwald, Anette and Haering, Julia and Schueler, Susanne and Ortmann, Olaf and Treeck, Oliver (2012) Effects of a Combined Treatment With GPR30 Agonist G-1 and Herceptin on Growth and Gene Expression of Human Breast Cancer Cell Lines. CANCER INVESTIGATION, 30 (5). pp. 372-379. ISSN 0735-7907,
Full text not available from this repository. (Request a copy)Abstract
Expression of G-protein-coupled receptor 30 (GPR30) is present in HER2-overexpressing breast cancer. In this study, we examined to what extent GPR30-agonist G-1 would affect the antitumoral action of trastuzumab (Herceptin). Combined treatment with both drugs exerted an additive growth-inhibitory effect on breast cancer cells which was accompanied by a significant decline of cyclin A2 expression both on the protein and the mRNA level. Combined treatment also resulted in expression changes of c-fos, cyclin D1, or p21/WAF-1. The results of our study encourage further attempts to test the relevance of these in vitro data in the clinical setting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-COUPLED RECEPTOR-30; ESTROGEN-RECEPTOR; PLASMA-MEMBRANE; G-PROTEIN-COUPLED-RECEPTOR-30 GPR30; PROLIFERATION; ACTIVATION; TRANSACTIVATION; ASSOCIATION; MIGRATION; THERAPY; GPR30; G-1; Breast cancer; Trastuzumab; Combined treatment; Gene expression |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2020 06:38 |
| Last Modified: | 13 May 2020 06:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18683 |
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