Skrzypczak, Maciej and Springwald, Anette and Lattrich, Claus and Haering, Julia and Schueler, Susanne and Ortmann, Olaf and Treeck, Oliver (2012) Expression of Cysteine Protease Cathepsin L is Increased in Endometrial Cancer and Correlates With Expression of Growth Regulatory Genes. CANCER INVESTIGATION, 30 (5). pp. 398-403. ISSN 0735-7907, 1532-4192
Full text not available from this repository. (Request a copy)Abstract
Proteases contribute to tumor invasion and metastasis by degrading basement membranes and extracellular matrix (ECM). In this study, we compared gene expression levels of two proteases, cysteine protease Cathepsin L2 (CTSL2) and matrix metalloproteinase MMP11, in human endometrium and endometrial cancer. Our data demonstrate CTSL2 transcript levels to be strongly elevated in endometrial cancer, particularly in G3 tumors. Furthermore, we observed a highly significant positive correlation of CTSL2 with expression of growth regulatory genes Ki-67, cyclin B1, MYBL2, p21/WAF, and HER2 receptor tyrosine kinase. Our data suggest that CTSL2 might be involved in progression of endometrial cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEROID-RECEPTORS; KI-67 EXPRESSION; CELL; CARCINOMA; STROMELYSIN-3; METASTASIS; INVASION; ROLES; BETA; PROGESTERONE; Cathepsin L; Endometrium; Endometrial cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2020 06:40 |
| Last Modified: | 13 May 2020 06:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18684 |
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