Girlich, C. and Schacherer, D. and Jung, E. M. and Schreyer, A. and Buettner, R. (2012) Comparison between a clinical activity index (Harvey-Bradshaw-Index), laboratory inflammation markers and quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound in Crohn's disease. EUROPEAN JOURNAL OF RADIOLOGY, 81 (6). pp. 1105-1109. ISSN 0720-048X,
Full text not available from this repository. (Request a copy)Abstract
Purpose: Due to its character as a remitting inflammatory disease, patients suffering from Crohn's disease (CD) often undergo several imaging studies subjecting the mostly young patients to ionizing. Contrast enhanced ultrasound for capillary microvascular assessment might be a new diagnostic tool for identifying the activity of inflammation by ultrasound techniques. Materials and methods: We prospectively evaluated 45 patients with proven Crohn's disease performing contrast enhanced ultrasound (CEUS) and laboratory assessment including C-reactive protein (CRP), leucocytes and hematocrit as well as calculating the Harvey-Bradshaw Index (HBI). Thereafter, we applied the quantification software Qontrast (R) to obtain contrast-enhanced sonographic perfusion maps. Results: Analysis of the 41 finally included patients revealed a correlation of CRP to HBI and TTP[s], respectively. Moreover, an association was found for HBI and TTP[s] and for HBI and TTP[s]/Peak [%]. Analysis of 34 patients with a Peak [%] >= 25 showed a close association of HBI and CRP. Besides, in these patients CRP correlated to TTP[s] and to TTP[s]/Peak [%]. We found a strong negative correlation between HBI and TTP[s] (r = -0.645, p < 0.01), thus, the higher the clinical activity the shorter the time-to-peak. Conclusion: Quantitative evaluation with CEUS, particularly the calculation of TTP[s] in patients with a Peak [%] >= 25, provides a simple method to assess the inflammatory activity in CD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORRELATE; Crohn's disease; Contrast enhanced ultrasound; Bowel; Clinical activity |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2020 08:28 |
| Last Modified: | 13 May 2020 08:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18701 |
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