Justinger, Christoph and Schilling, Martin K. and Kees, Martin G. and Kauffels, Anne and Hirschmann, Katrin and Kopp, Berit and Kees, Frieder and Kollmar, Otto (2012) Penetration of moxifloxacin into liver tissue. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 39 (6). pp. 505-509. ISSN 0924-8579,
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Moxifloxacin is considered for treatment of pyogenic liver abscesses as well as antibiotic prophylaxis in the case of hepatobiliary interventions. The aim of this study was to provide data on the pharmacokinetic (PK) profile of moxifloxacin in serum and liver tissue of patients undergoing liver resection due to primary or secondary tumours of the liver. Patients scheduled for liver resection (n = 34) received moxifloxacin 400 mg at randomised time intervals prior to surgery. Blood and healthy liver tissue were sampled 1.5-26 h after administration of moxifloxacin. Immediately after centrifugation, plasma was separated, frozen and stored until analysis. In a subgroup of 19 patients, additional plasma specimens were obtained after 2, 4, 8, 12, 24, 36 and 48 h to assess the PK profile. PK parameters of moxifloxacin were calculated applying a two-compartment model. Median (interquartile range) PK parameters were as follows: peak concentration at the end of moxifloxacin infusion (C-max), 6.0 mg/L (4.8-7.1 mg/L); area under the concentration-time curve extrapolated to infinity (AUC(0-infinity)), 51.1 mg h/L (40.3-57.7 mg h/L); elimination half-life, 13.2 h (11.0-14.1 h); volume of distribution at steady state (V-ss), 138.7 L (102.7-168.5 L); and total body clearance (CL), 7.8 L/h (6.9-9.9 L/h). Mean tissue concentrations were 9.13 mg/kg after 1.6-2.4 h, 7.62 mg/kg after 2.6-4.9 h, 7.48 mg/kg after 5.6-10.0 h and 6.24 mg/kg after 22.9-26.5 h. Mean tissue: serum ratios were 2.9, 3.4, 5.0 and 12.3, respectively. The lowest tissue concentration found in the study at any time point was 2.8 mg/kg. In conclusion, moxifloxacin rapidly penetrates into the liver tissue where its concentration remains high following intravenous administration. Therefore, intravenously applied moxifloxacin might be used for the treatment of bacterial liver infections such as pyogenic liver abscess as well as in pre-operative prophylaxis. (c) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BILIARY-TRACT; ABSCESS; PHARMACOKINETICS; CHOLANGITIS; INFECTIONS; MANAGEMENT; ETIOLOGY; SURGERY; TRENDS; Moxifloxacin; Liver penetration; Pharmacokinetics; Liver abscess |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2020 08:50 |
| Last Modified: | 13 May 2020 08:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18702 |
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