Schaedlich, Andreas and Hoffmann, Stefan and Mueller, Thomas and Caysa, Henrike and Rose, Cornelia and Goepferich, Achim and Li, Jun and Kuntsche, Judith and Maeder, Karsten (2012) Accumulation of nanocarriers in the ovary: A neglected toxicity risk? JOURNAL OF CONTROLLED RELEASE, 160 (1). pp. 105-112. ISSN 0168-3659,
Full text not available from this repository. (Request a copy)Abstract
Several nanocarrier systems are frequently used in modern pharmaceutical therapies. Within this study a potential toxicity risk of all nanoscaled drug delivery systems was found. An accumulation of several structurally different nanocarriers but not of soluble polymers was detected in rodent ovaries after intravenous (i.v.) administration. Studies in different mouse species and Wistar rats were conducted and a high local accumulation of nanoparticles, nanocapsules and nanoemulsions in specific locations of the ovaries was found in all animals. We characterised the enrichment by in vivo and ex vivo multispectral fluorescence imaging and confocal laser scanning microscopy. The findings of this study emphasise the role of early and comprehensive in vivo studies in pharmaceutical research. Nanocarrier accumulation in the ovaries may also comprise an important toxicity issue in humans but the results might as well open a new field of targeted ovarian therapies. (C) 2012 Elsevier B. V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLY(METHYL METHACRYLATE) NANOPARTICLES; IN-VIVO BIODISTRIBUTION; BODY DISTRIBUTION; DRUG-DELIVERY; LIPOSOME SIZE; QUANTUM DOTS; TUMOR-MODEL; CELLS; SURFACTANTS; CLEARANCE; Nanocarrier; Nanoparticle; Toxicity; In vivo imaging; Fluorescence imaging; Ovary |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2020 09:13 |
| Last Modified: | 13 May 2020 09:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18708 |
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