Okimoto, Naoki and Bosch, Oliver J. and Slattery, David A. and Pflaum, Konstanze and Matsushita, Hiroaki and Wei, Fan-Yan and Ohmori, Masayasu and Nishiki, Tei-ichi and Ohmori, Iori and Hiramatsu, Yuji and Matsui, Hideki and Neumann, Inga D. and Tomizawa, Kazuhito (2012) RGS2 mediates the anxiolytic effect of oxytocin. BRAIN RESEARCH, 1453. pp. 26-33. ISSN 0006-8993, 1872-6240
Full text not available from this repository. (Request a copy)Abstract
The neuropeptide oxytocin (OT) has been shown to exert multiple functions in both males and females, and to play a key role in the regulation of emotionality in the central nervous system (CNS). OT has an anxiolytic effect in the CNS of rodents and humans. However, the molecular mechanisms of this effect are unclear. Here we show that OT induced the expression of regulator of G-protein signaling 2 (RGS2), a regulatory factor for anxiety, in the central amygdala (CeA) of female mice. Bath application of OT increased RGS2 levels in slices of the amygdala of virgin mice. RGS2 levels in the CeA were higher in lactating mice than in virgin mice. In contrast, RGS2 levels in mice that had given birth did not increase when the pups were removed. Acute restraint stress for 4 h induced RGS2 expression within the CeA, and local administration of an OT receptor antagonist inhibited this expression. Behavioral experiments revealed that transient restraint stress had an anxiolytic effect in wild-type females, and RGS2 levels in the CeA correlated with the anxiolytic behavior. By contrast, in the OT receptor-deficient mice, restraint stress neither increased RGS2 levels in the CeA nor had an anxiolytic effect. These results suggest that OT displays an anxiolytic effect through the induction of RGS2 expression in the CNS. (C) 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; PITUITARY-ADRENAL AXIS; BRAIN OXYTOCIN; MALE RATS; GENE POLYMORPHISMS; CENTRAL AMYGDALA; ANXIETY; VASOPRESSIN; BEHAVIOR; STRESS; Anxiety; Stress; Amygdala; Female; Mouse |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2020 05:30 |
| Last Modified: | 14 May 2020 05:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18746 |
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