Krumbholz, Andi and Mohn, Ulrich and Lange, Jeannette and Motz, Manfred and Wenzel, Juergen J. and Jilg, Wolfgang and Walther, Mario and Straube, Eberhard and Wutzler, Peter and Zell, Roland (2012) Prevalence of hepatitis E virus-specific antibodies in humans with occupational exposure to pigs. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 201 (2). pp. 239-244. ISSN 0300-8584,
Full text not available from this repository. (Request a copy)Abstract
Due to the increasing number of non-travel-associated hepatitis E virus (HEV) infections observed in several industrialised countries including Germany, there is a substantial interest in the characterisation of risk factors and transmission routes relevant to autochthonous HEV infections. Autochthonous cases are believed to be the result of a zoonotic HEV transmission from pigs, wild boars and deer. Recently, a high prevalence of HEV-specific antibodies in the German domestic pig population has been demonstrated. Thus, one may assume a higher prevalence of HEV-specific antibodies in humans with occupational exposure to pigs. In this study, sera obtained from 24 slaughterers, 14 meat inspectors, 46 pig farmers and 22 veterinarians were tested for the presence of HEV-specific antibodies using a line immunoassay. For comparison, sera obtained from 116 age- and gender-matched blood donors were also included. Twenty eight per cent (28.3%; 30/106) of the swine-exposed humans and 15.5% (18/116) of the blood donors without contact to pigs exhibited IgG-antibodies determined as reactive (i.e. borderline or positive) against HEV. Thus, an increased risk of HEV infection in humans occupationally exposed to pigs and particularly for slaughterers (41.7%; 10/24) was demonstrated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFECTION; GERMANY; DISEASE; EPIDEMIOLOGY; TRANSMISSION; FARMERS; RISK; Zoonosis; Genotype; Immunoassay; Seroprevalence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 May 2020 05:41 |
| Last Modified: | 15 May 2020 05:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18799 |
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