Wohlschlaeger, J. and Milting, H. and Stypmann, J. and Hager, T. and Schmid, C. and Levkau, B. and Baba, H. A. (2012) Congestive heart failure. Reverse cardiac remodeling mediated by left ventricular assist devices. PATHOLOGE, 33 (3). 175-+. ISSN 0172-8113,
Full text not available from this repository. (Request a copy)Abstract
Left ventricular assist devices (LVAD) are currently used to treat patients with terminal congestive heart failure as a bridge to transplantation or as destination therapy in individuals with contraindications for cardiac transplantation. The LVADs are pulsatile or non-pulsatile systems that transport blood from the left ventricle to the ascending aorta parallel to the circulation thus providing a profound volume and pressure reduction in the left ventricle. The use of LVADs is associated with a considerable decrease of cardiac hypertrophy and dilation with significantly improved cardiac performance in a small subset of patients. The underlying process is termed reverse cardiac remodelling and is characterized by a significant decrease in the size of cardiomyocytes and reversible regulation of numerous molecular systems in the myocardium.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FAILING HUMAN HEART; UBIQUITIN-PROTEASOME SYSTEM; ACTIVATED PROTEIN-KINASES; STEM-CELLS; MECHANICAL SUPPORT; DOWN-REGULATION; HYPERTROPHY; MYOCARDIUM; EXPRESSION; CYCLOOXYGENASE-2; Congestive heart failure; Left ventricular assist devices; Reverse cardiac remodeling; Cardiac transplantation; Cardiac hypertrophy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 May 2020 05:45 |
| Last Modified: | 15 May 2020 05:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18802 |
Actions (login required)
 |
View Item |
