Skodacek, Daniel and Arnold, Ulrike and Storck, Katharina and Alvarez, Carmelo Perez and Ratzinger, Sabine and Staudenmaier, Rainer (2012) Chondrocytes suspended in modified fibrin glue for vocal fold augmentation: An in vitro study in a porcine larynx model. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 34 (5). pp. 667-673. ISSN 1043-3074,
Full text not available from this repository. (Request a copy)Abstract
Background Injection laryngoplasty is an option for treatment of dysphonia following vocal fold paralysis. Modified fibrin glue with suspended chondrocytes might be a favorable cell-based material for permanent vocal fold medialization. Methods. We compared fibrin glue with suspended chondrocytes to collagen and hyaluronic acid gels concerning alteration of vocal fold vibration and correct intralaryngeal placement after intralaryngeal injection into porcine larynges. Viscoelastic properties of the materials were analyzed by means of a parallel plate rheometer. Results. Fibrin glue with cells was comparable to collagen and hyaluronic acid with respect to amplitudes, symmetry, and periodicity of vocal fold vibration. Application and positioning of fibrin glue with suspended chondrocytes were technically undemanding and comparable with controls. Complex stress modulus of fibrin glue with suspended cells was comparable to that of collagen gel. Conclusions. Fibrin glue with suspended chondrocytes seems suitable for the indication of injection laryngoplasty and holds promise for permanent vocal fold medialization. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 667-673, 2012
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CALCIUM HYDROXYLAPATITE; COLLAGEN INJECTION; PARALYSIS; CORD; BIOMATERIALS; SURGERY; CANINE; GELS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2020 09:45 |
| Last Modified: | 14 May 2020 09:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18852 |
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