Moder, Daniel and Taubenhansl, Frederike and Hiller, Karl-Anton and Schmalz, Gottfried and Christgau, Michael (2012) Influence of autogenous platelet concentrate on combined GTR/graft therapy in intrabony defects: a 7-year follow-up of a randomized prospective clinical split-mouth study. JOURNAL OF CLINICAL PERIODONTOLOGY, 39 (5). pp. 457-465. ISSN 0303-6979, 1600-051X
Full text not available from this repository. (Request a copy)Abstract
Objectives: To investigate the influence of autogenous platelet concentrate (APC) on the long-term regeneration outcome 7 years after guided tissue regeneration (GTR) in deep intrabony periodontal defects. Material and Methods: In 25 patients, two deep contra-lateral intrabony defects were treated according to GTR (randomized split-mouth-design). In the test defects, APC was additionally applied. After 7 years, healing results were assessed clinically by a blinded examiner and compared to baseline and 12-months results. Furthermore, a tooth survival analysis was performed. Results: After 7 years, 23 patients were available for survival analysis and 16 patients for split-mouth analysis; 84% of the test and control teeth were still in situ. In both groups, the median attachment level of 10.5 mm [(25/75%): test 9.0/13.0, control 10.0/12.0] at baseline was significantly (p <= 0.05) reduced to 6.0 mm [test 4.0/6.8, control 5.0/7.0] after 1 year. Six years later, it had increased again to 7.0 mm in test sites [5.3/10.0] (p <= 0.05) and had remained stable in control sites [5.0/7.8] (p > 0.05). Bleeding on Probing (BOP) had increased in both groups. During the last 6 years, only 26% of the patients received a structured supportive periodontal therapy in the clinic. Conclusion: Within its limitations, the present study indicates that the clinical outcome of GTR therapy can be maintained over 7 years. However, the additional use of APC may even have a possibly negative influence on the long-term stability.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GUIDED TISSUE REGENERATION; GROWTH FACTOR-BB; EXPANDED POLYTETRAFLUOROETHYLENE MEMBRANES; PERIODONTAL-LIGAMENT CELLS; BOVINE-DERIVED XENOGRAFT; ENAMEL MATRIX PROTEINS; LONG-TERM STABILITY; RICH PLASMA; INFRABONY DEFECTS; BONY DEFECTS; guided tissue regeneration; intrabony defects; long-term results; membranes; periodontal disease; surgery; platelets; tricalcium phosphate |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2020 09:46 |
| Last Modified: | 14 May 2020 09:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18853 |
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