Stradalova, Vendula and Blazikova, Michaela and Grossmann, Guido and Opekarova, Miroslava and Tanner, Widmar and Malinsky, Jan (2012) Distribution of Cortical Endoplasmic Reticulum Determines Positioning of Endocytic Events in Yeast Plasma Membrane. PLOS ONE, 7 (4): e35132. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
In many eukaryotes, a significant part of the plasma membrane is closely associated with the dynamic meshwork of cortical endoplasmic reticulum (cortical ER). We mapped temporal variations in the local coverage of the yeast plasma membrane with cortical ER pattern and identified micron-sized plasma membrane domains clearly different in cortical ER persistence. We show that clathrin-mediated endocytosis is initiated outside the cortical ER-covered plasma membrane zones. These cortical ER-covered zones are highly dynamic but do not overlap with the immobile and also endocytosis-inactive membrane compartment of Can1 (MCC) and the subjacent eisosomes. The eisosomal component Pil1 is shown to regulate the distribution of cortical ER and thus the accessibility of the plasma membrane for endocytosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NUCLEUS-VACUOLE JUNCTIONS; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; CELL; ER; COMPARTMENTATION; MICRODOMAINS; ORGANIZATION; PROTEINS; LIPIDS; |
| Subjects: | 500 Science > 580 Botanical sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Lehrstuhl für Zellbiologie und Pflanzenphysiologie (Prof. Dr. Klaus Grasser) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 May 2020 04:50 |
| Last Modified: | 15 May 2020 04:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18896 |
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