Lechler, P. and Handel, M. and Anders, S. and Balakrishnan, S. and Grifka, J. (2012) The oncofetal gene survivin - a possible target gene for regenerative therapy concepts in cartilaginous tissue. ORTHOPADE, 41 (4). pp. 260-267. ISSN 0085-4530,
Full text not available from this repository. (Request a copy)Abstract
Survivin, the smallest member of the inhibitor of the apoptosis protein gene family (IAP) is a key molecule for mammalian cell cycle regulation and cellular survival. Of note these functions have been thought to be limited to embryonic and malignant tissues. However, a growing body of evidence indicates a limited expression of survivin in some highly specific adult tissues and cells. In the present study it has been demonstrated that the antiapoptotic protein survivin is re-expressed in osteoarthritic human cartilage and primary human chondrocytes. Furthermore, the data indicated that survivin significantly affects cell cycle regulation and cellular survival. The modulation of survivin expression and function in cartilaginous tissues might be important for understanding osteoarthritis and the development of regenerative strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VITRO; ARTICULAR-CARTILAGE; APOPTOSIS; CHONDROCYTES; MECHANISMS; INHIBITOR; PROTEINS; DEATH; CELLS; Survivin; Chondrocyte; Apoptosis; Mitosis; Osteoarthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 May 2020 05:18 |
| Last Modified: | 15 May 2020 05:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18910 |
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