Durand, Morgan and Stoppa, Alexander and Molinier, Valerie and Touraud, Didier and Aubry, Jean-Marie (2012) Toward the Rationalization of Facilitated Hydrotropy: Investigation with the Ternary Dimethyl Isosorbide/Benzyl Alcohol/Water System. JOURNAL OF SOLUTION CHEMISTRY, 41 (3). pp. 555-565. ISSN 0095-9782,
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Solubility enhancement has been achieved by facilitated hydrotropy for the dimethyl isosorbide (DMI) / benzyl alcohol / water system. Facilitated hydrotropy has been studied via three different approaches: the solubilization in water of a hydrophobic dye, the evolution of the surface tension and dynamic light scattering, all as a function of the benzyl alcohol concentration. The facilitated hydrotropy has been rationalized from the solubilization properties of the system according to the ratio between the insoluble hydrotrope (here benzyl alcohol, a preservative used in parenteral injections) and the bio-sourced co-solvant (here the dimethyl isosorbide ether, DMI, a solvent used in pharmaceutical formulation). The presence of self-associated nanostructures has been detected by dynamic light scattering (DLS). It appears that the cosolvent, DMI, has an antagonistic action: DMI increases the facilitated hydrotrope (benzyl alcohol) solubility in the aqueous solution (favoring solute solubilization) but simultaneously decreases the hydrotropic efficiency of benzyl alcohol.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SOLUBILIZATION; AGGREGATION; FORMULATION; SOLVENT; Facilitated hydrotropy; Solubilization enhancement; Dynamic light scattering |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 May 2020 05:32 |
| Last Modified: | 15 May 2020 05:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18914 |
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