Kaelble, T. and Hofmann, I. and Thueroff, J. W. and Stein, R. and Hautmann, R. and Riedmiller, H. and Vergho, D. and Hertle, L. and Wuelfing, C. and Truss, M. and Roth, S. and von Rundstedt, F. C. and Albers, P. and Gschwend, J. and Herkommer, K. and Humke, U. and Spahn, M. and Bader, P. and Steffens, J. and Harzmann, R. and Stief, C. G. and Karl, A. and Mueller, S. C. and Waldner, M. and Noldus, J. and Kleinschmidt, K. and Alken, P. and Kopper, B. and Fisch, M. and Lampel, A. and Stenzel, A. and Fichtner, J. and Flath, B. and Ruebben, H. and Juenemann, K. P. and Hautmann, S. and Knipper, A. and Leusmann, D. and Strohmaier, W. and Thon, W. F. and Miller, S. and Weingaertner, K. and Schilling, A. and Piechota, H. and Becht, J. E. and Schwaibold, H. and Bub, P. and Conrad, S. and Wenderoth, U. and Merkle, W. and Roesch, W. and Otto, T. and Ulshoefer, B. and Westenfelder, M. (2012) Secondary malignancies in urinary diversions. UROLOGE, 51 (4). 500-+. ISSN 0340-2592,
Full text not available from this repository. (Request a copy)Abstract
In contrast to ureterosigmoidostomy no reliable clinical data exist for tumor risk in different forms of urinary diversion using isolated intestinal segments. In 44 German urological departments, operation frequencies, indications, patient age, and operation dates of the different forms of urinary diversion, operated between 1970 and 2007, could be registered. The secondary tumors up to 2009 were registered as well and related to the numbers of the different forms of urinary diversions resulting in tumor prevalences. In 17,758 urinary diversions 32 secondary tumors occurred. The tumor risk in ureterosigmoidostomy (22=fold) and cystoplasty (13=fold) is significantly higher than in other continent forms of urinary diversion such as neobladders or pouches (p<0.0001). The difference between ureterosigmoidostomy and cystoplasty is not significant, nor is the difference between ileocecal pouches (0.14%) and ileal neobladders (0.05%) (p=0.46). The tumor risk in ileocecal (1.26%) and colonic neobladders (1.43%) is significantly higher (p=0.0001) than in ileal neobladders (0.5%). Of the 16 tumors that occurred following ureterosigmoidostomy, 16 (94%) developed directly at the ureterocolonic borderline in contrast to only 50% following urinary diversions via isolated intestinal segments. From postoperative year 5 regular endoscopic controls of ureterosigmoidostomies, cystoplasties, and orthotopic (ileo-)colonic neobladders are necessary. In ileocecal pouches, regular endoscopy is necessary at least in the presence of symptoms or should be performed routinely at greater intervals. Following neobladders or conduits, only urethroscopies for urethral recurrence are necessary.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTESTINAL SEGMENTS; TUMOR-INDUCTION; DIFFERENT FORMS; RAT MODEL; URETEROSIGMOIDOSTOMY; CARCINOGENESIS; TRACT; CARCINOMA; CANCER; Urinary diversion; Intestinal segments; Ureterosigmoidostomy; Secondary tumor |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 May 2020 05:57 |
| Last Modified: | 15 May 2020 05:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18918 |
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