Treiber, Thomas and Treiber, Nora and Meister, Gunter (2012) Regulation of microRNA biogenesis and function. THROMBOSIS AND HAEMOSTASIS, 107 (4). pp. 605-610. ISSN 0340-6245,
Full text not available from this repository. (Request a copy)Abstract
MicroRNAs (miRNAs) are considered as key regulators of literally all cellular pathways. Therefore, miRNA biosynthesis and their individual cellular functions must be tightly regulated as well. MiRNAs are transcribed as primary transcripts, which are processed to mature miRNAs in two consecutive maturation steps. Finally, the mature miRNA is incorporated into a miRNA-protein complex, where it directly interacts with a member of the Argonaute (Ago) protein family. The miRNA guides such protein complexes to partial complementary target sites, which are typically located in the 3' untranslated region (UTR) of mRNAs leading to inhibition of gene expression. MiRNA activity and abundance is regulated on various levels ranging from transcription and processing to target site binding and miRNA stability. Recent advances in our understanding of how miRNA activity is regulated in mammalian cells are summarised and discussed in this review article.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EMBRYONIC STEM-CELLS; NUCLEAR EXPORT; POSTTRANSCRIPTIONAL REGULATION; BINDING PROTEIN; MESSENGER-RNAS; DIFFERENTIAL REGULATION; MICROPROCESSOR COMPLEX; CAENORHABDITIS-ELEGANS; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; microRNAs; Dicer; Drosha; Argonaute; gene silencing |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 May 2020 06:04 |
| Last Modified: | 18 May 2020 06:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18925 |
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