Schaeffler, Andreas and Buechler, Christa (2012) CTRP family: linking immunity to metabolism. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 23 (4). pp. 194-204. ISSN 1043-2760
Full text not available from this repository. (Request a copy)Abstract
It is well known that infectious and inflammatory diseases such as sepsis and severe inflammatory response syndrome are accompanied by metabolic alterations such as insulin resistance. Conversely, metabolic diseases such as visceral obesity and type 2 diabetes are characterized by high levels of proinflammatory cytokines. Metabolism and immunity are linked by proteins of dual function. Adiponectin, a member of the C1q/TNF-related protein (CTRP) family, has attracted much interest because of its anti-inflammatory and insulin-sensitizing effects. To date, 15 additional CTRP family members have been identified that might also play a role in metabolism and immunity. This review focuses on the biochemistry and pleiotropic physiological functions of CTRPs as new molecular mediators connecting inflammatory and metabolic diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; REPEAT-CONTAINING SEQUENCE; ONSET RETINAL DEGENERATION; GENOME-WIDE ASSOCIATION; VISCERAL ADIPOSE-TISSUE; HIGH-LEVEL EXPRESSION; HUMAN MONOCYTIC CELLS; RAT OBESE CDNA; MACULAR DEGENERATION; COLLAGENOUS REPEAT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 11 May 2020 10:19 |
| Last Modified: | 11 May 2020 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/18965 |
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